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Natural forgetting reversibly modulates engram expression

James D. O'Leary, Rasmus Bruckner, Livia Autore, Tomás J. Ryan

5 December 2023



Engram cell connectivity as a mechanism for information encoding and memory function

Clara Ortega-de San Luis, Maurizio Pezzoli, Esteban Urrieta, Tomás J. Ryan

21 November 2023

Current Biology


Immune activation state modulates retrieval of infant engrams

Sarah D. Power, Erika Stewart, Louisa G. Zielke, Eric Patrick Byrne, Clara Ortega-de San Luis, Lydia Lynch, Tomás J. Ryan

8 November 2023

Science Advances


Adaptive expression of engrams by retroactive interference

Livia Autore, James D. O’Leary, Clara Ortega-de San Luis, Tomás J. Ryan

29 August 2023

Cell Reports


Understanding the physical basis of memory: Molecular mechanisms of the engram

Clara Ortega-de San Luis and Tomás J. Ryan

26 March 2022

JBC Reviews


Forgetting as a form of adaptive engram cell plasticity

Tomás J. Ryan & Paul W. Frankland

13 January 2022

Nature Reviews Neuroscience


Engram cell connectivity: an evolving substrate for information storage

Tomás J. Ryan, Clara Ortega-de San Luis, Maurizio Pezzoli & Siddhartha Sen

31 March 2021

Journal of Biological Chemistry


Memory: it's not a lie if you believe it

Livia Autore & Tomás J. Ryan

22 June 2020

Current Biology


United states of amnesia: rescuing memory loss from diverse conditions

Clara Ortega-de San Luis, Tomás J. Ryan

18 May 2018

Disease Models & Mechanisms


Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of DAPK1

Jamie McQueen, Tomas J Ryan, Sean McKay, Katie FM Marwick, Paul E Baxter, Sarah M Carpanini, Thomas M Wishart, Thomas H Gillingwater, Jean C Manson, David JA Wyllie, Seth GN Grant, Barry McColl, Noboru Komiyama, Giles E Hardingham

21 July 2017



On the research of time past: the hunt for the substrate of memory

Bridget N. Queenan, Tomás J. Ryan, Michael S. Gazzaniga, and Charles R. Gallistel

26 May 2017

Annals of the New York Academy of Sciences


What is memory? The present state of the engram

Mu-ming Poo, Michele Pignatelli, Tomás J. Ryan, Susumu Tonegawa, Tobias Bonhoeffer, Kelsey C. Martin, Andrii Rudenko, Li-Huei Tsai, Richard W. Tsien, Gord Fishell, Caitlin Mullins, J. Tiago Gonçalves, Matthew Shtrahman, Stephen T. Johnston, Fred H. Gage, Yang Dan, John Long, György Buzsáki, Charles Stevens

19 May 2016

BMC Biology


NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation

Rene A.W. Frank, Noboru H. Komiyama, Tomás J. Ryan, Fei Zhu, Thomas J. O’Dell & Seth G.N. Grant

27 April 2016

Nature Communications


Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

Dheeraj S. Roy, Autumn Arons, Teryn I. Mitchell, Michele Pignatelli, Tomás J. Ryan & Susumu Tonegawa

16 March 2016



Rehebbilitating Memory

Tomás J Ryan and Susumu Tonegawa

10 December 2015



Memory engram storage and retrieval

Susumu Tonegawa, Michele Pignatelli, Dheeraj S. Roy, Tomás J. Ryan

1 December 2015

Current Opinion in Neurobiology


Engram cells retain memory under retrograde amnesia

Tomás J. Ryan, Dheeraj S. Roy, Michele Pignatelli, Autumn Arons, Susumu Tonegawa

29 May 2015



Creating a False Memory in the Hippocampus

Steve Ramirez, Xu Liu, Pei-Ann Lin, Junghyup Suh, Michele Pignatelli, Roger L Redondo, Tomás J. Ryan, Susumu Tonegawa

26 July 2013



Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior

Tomás J Ryan, Maksym V Kopanitsa, Tim Indersmitten, Jess Nithianantharajah, Nurudeen O Afinowi, Charles Pettit, Lianne E Stanford, Rolf Sprengel, Lisa M Saksida, Timothy J Bussey, Thomas J O’Dell, Seth G N Grant & Noboru H Komiyama

2 December 2012

Nature Neuroscience


The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults

Marc-André Martel, Tomás J Ryan, Karen F.S. Bell, Jill H. Fowler, Aoife McMahon, Bashayer Al-Mubarak, Noboru H. Komiyama, Karen Horsburgh, Peter C. Kind, Seth G.N. Grant, David J.A. Wyllie, and Giles E. Hardingham

10 May 2012



The origin and evolution of synapses

Tomás J. Ryan and Seth G. N. Grant

9 September 2009

Nature Reviews Neuroscience


Evolution of NMDA receptor cytoplasmic interaction domains: Implications for organisation of synaptic signalling complexes

Tomás J. Ryan, Richard D Emes, Seth G.N. Grant and Noboru H Komiyama

15 January 2008

BMC Neuroscience

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